Last edited by Doushura
Tuesday, August 4, 2020 | History

5 edition of Cisplatin found in the catalog.

Cisplatin

by A.W. Prestayko

  • 245 Want to read
  • 20 Currently reading

Published by Academic Press Inc.,U.S. .
Written in English


The Physical Object
Number of Pages542
ID Numbers
Open LibraryOL7328630M
ISBN 100125650507
ISBN 109780125650502

Cisplatin is a platinum-containing chemotherapy drug. Although the mechanism of action is not understood completely, cisplatin behaves similarly to a bi-functional alkylating agent by producing cross links in DNA. Cisplatin is distributed widely into the liver, kidney and intestines and is distributed poorly into the central nervous system (CNS). Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient&#x;s quality of life. It is paramount for health care practitioners managing such patients to be aware of cisplatin&#x;s ototoxic properties and the clinical signs to.

Cisplatin is a generic medicine name and there are several brands available for it. Some of the brands for cisplatin might be better known than cisplatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cisplatin in stock, you can ask for one of the branded alternatives for cisplatin. Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic.

Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur during treatment or weeks after stopping treatment. Cisplatin's widespread use is due to it effectiveness, so the benefits outweigh the detractions much of the time. Also, since cisplatin has well-known and widely documented effects and side-effects, it can be used as a base treatment to provide consistent care for the patient while testing the effectiveness and side effects of another drug.


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Cisplatin by A.W. Prestayko Download PDF EPUB FB2

Publisher Summary. Cisplatin (cis-dichlorodiammineplatinum II) is the first member of a Cisplatin book class of potent Cisplatin book drugs, the metal coordination complexes, to enter general use in cancer drug has been proved to be effective alone or in combination for the treatment of a wide variety of solid cancers in man.

Cisplatin: Pharmacology, Clinical Uses and Adverse Effects (Pharmacology - Research, Safety Testing and Regulation: Cancer Etiology, Diagnosis and Treatments): Medicine & Health Science Books @ ce: $ Cisplatin is an antineoplastic agent. Cisplatin, while highly toxic, is one of the most heavily utilized chemotherapeutic agents for hematologic and solid tumor malignancies.

It can be used as a single-agent Cisplatin book in combination therapy for induction and neoadjuvant therapy. Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer.

Cisplatin has been associated with a low rate of serum enzyme elevations and with rare. 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to. Description Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Book Edition: 1.

Cisplatin is a square–planar complex, containing two labile chlorines and two relatively inert ammonia molecules coordinated to the central Pt (II) atom in a cis configuration.

From: Medicinal Chemistry of Anticancer Drugs (Second Edition),   Use birth control to prevent pregnancy while taking cisplatin and for 14 months after your last dose. If you get pregnant while taking cisplatin or within 14 months after your last dose, call your doctor right away.

How is this medicine (Cisplatin) best taken. Use cisplatin as ordered by your doctor. Read all information given to you. From Wikipedia, the free encyclopedia Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma.

It is given by injection into a vein. About this book 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field.

each course of cisplatin to detect nephrotoxicity. MaycauseqBUN and creatinine andpcalcium, magnesium, phosphate, sodium, and potassium levelsthat usually occur the 2nd wk after a dose. Do not administer additional doses until BUN is 25 mg/ mL and serum creatinine is mg/ mL. May causequric acid level,whichusuallypeaks3–5daysafteradose.

Approved Drug Products containing Cisplatin listed in the FDA Orange Book. Original Data: FDA Website. Cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Cisplatin. Rosenberg's keen observation in led, 18 years later, to Food and Drug Administration (FDA) approval of cisplatin. The drug's conception, gestation, and birth illustrate the scientific process and also the importance of following even the strangest of hunches.

cisplatin ove rdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle. DESCRIPTION. Cisplatin Injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials.

Each 50 mL or mL amber vial of infusion concentrate contains: 1 mg/mL. Cisplatin concentrations decrease monoexponentially with a half-life of approximately 20 to 30 minutes. Red blood cell platinum concentrations decline in a biphasic manner with a terminal half-life of 36 to 47 days.

Cisplatin is excreted in the urine, with 13% to 17% of a 50 mg/m2 dose in the urine within 1 hour of administration. Cisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated with cisplatin for injection and may be so severe that drug must be discontinued.

Cisplatin. Cisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. How cisplatin works. This chemotherapy drug destroys quickly dividing cells, such as cancer cells. This book compiles in six Parts the various aspects of chemistry, biochemistry, biology, pharmacology, and medicine relevant to cisplatin, describing new links that suggest how cisplatin may trigger a cascade of cellular events that result ultimately in apoptosis.

Cisplatin is a chemotherapy drug used to treat malignant mesothelioma cancer. Request a free book for more information on treatment & mesothelioma lawyers. (cisplatin for injection, USP) is a white to light yellow lyophilized powder. Each vial of PLATINOL contains 50 mg cisplatin, mg Sodium Chloride, USP, and mg Mannitol, USP.

The active ingredient, cisplatin, is a yellow to orange crystalline powder with the molecular formula PtCl.

2. H. 6. N. 2, and a molecular weight of Cisplatin.CISplatin is a topic covered in the Davis's Drug Guide. To view the entire topic, please sign in or purchase a subscription. Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers + trade name and generic drugs.Extravasation is the non-intentional leakage of an intravenous agent from a vessel into the surrounding subcutaneous tissues.

Chemotherapeutic agents can be divided into vesicant, irritant and non-vesicant drugs ().Vesicant drugs have the potential to cause severe tissue necrosis and blistering and can be further divided into DNA-binding or non-DNA-binding subtypes.